ESPE Abstracts

Objectives: The aim was to clarify the associations of Irisin with obesity and early onset metabolic and vascular sequelae in Chinese children, and to examine whether the association between obesity and endothelial dysfunction and vascular Inflammation was mediated by Irisin.Methods: We quantified Irisin serum levels in 85 lean and 120 obese children and assessed associations with metabolic and cardiovascular parameters ...

Objective: Asprosin, a novel peptide that has recently discovered as an important regulatory adipokine, is relevant to obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of asprosin and explore its relationship to various obesity-related markers in children with obesity.Methods: A cross-sectional study was conducted among 119 ...

Background: Cell death-inducing DFF45-like effector C (CIDEC) is a novel lipid droplet-coating protein that promotes triglyceride accumulation and inhibits lipolysis. TNFα downregulates CIDEC levels to enhance basal lipolysis, while CIDEC overexpression could block this effect. However, the signalling mechanism by which TNFα regulates CIDEC expression in human is still unknown.Objective and hypotheses: The aim of this study was to investigate t...